OLR1(LOX1);

Oxidized low-density lipoprotein receptor 1(Ox-LDL receptor 1);

Lectin-type oxidized LDL receptor 1;Lectin-like oxidized LDL receptor 1(LOX-1;Lectin-like oxLDL receptor 1;bLOX-1);

Bovine (Bos taurus). 

Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Cell membrane Single-pass type II membrane protein Secreted A secreted form also exists.

270

N/A

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PF00059

P79391

Bt.367

bta:281368

P79391